Dr. Reto Brem

Projects: Studies on the combined effects of immunosuppressant/anti-cancer/anti-inflammatory drugs and UVA irradiation on genomic stability, with special focus on the induction of DNA strand breaks, DNA damage checkpoints and inhibition of transcription. Project management and supervision of Ph.D. students

Projects: Establishment of the essential role of XRCC1 in base excision repair (BER) in human cells/Role of the DNA damage sensors ATR and ATM in the induction of the S phase checkpoint in the absence of functional BER/Molecular epidemiology: The presence of SNPs in the XRCC1 gene and their association with breast cancer risk and response to radiotherapy. Supervision of technician

Projects: Expression profiling of an experimental model of cancer and precusor cell lines/Expression profiling of Interferon-resistant and responsive melanoma cell lines/Functional characterization of a family of Interferon-inducible genes

Cell Biology Molecular Biology Genetics Developmental Biology