Matthias Metzner

Manufacturing Science & Technology - Fill Finish Pilot Plant (Biologics): • Lead key projects to drive innovation roadmap (focus: combination products & drug product manufacturing) • Ensures that manufacturing relevant information and technical capabilities are in place to flawlessly produce combination products according to GxP and business requirements • Ensures that manufacturing processes are scalable and transferable to commercial operations

Manufacturing and Container Closure Sciences - Primary Packaging Development (Biologics) -Manufacturing process transfer and manufacturing support for CMOs and internal AbbVie manufacturing sites -Extractables & leachables (within Drug Product manufacturing): Manufacturing process materials like e.g. single-use bags, sterile filters, tubing, Primary packaging

- Drug Product Development (Biologics): • Establishment and optimization of manufacturing processes (aseptic manufacturing) of parenteral drugs (phase 1 to phase 3) • Coordination support of projects teams for the establishment of manufacturing processes including the manufacturing process transfer from development stage to the GMP-environment • Leadership of a “Center of Excellence” to the topic “Extractables & Leachables” • Management of the “Center for Excellence” ultra- and diafiltration

Master Thesis with the topic: Basic understanding of excipient and protein behaviour during dia- and ultrafiltration

Task: Optimization of a bacteria-concentrator for blood as a pre-step for a fast detection of bacteremia in blood

Bachelor Thesis with the topic: Models for the amyloid-beta-induced signal transduction and the cultivation of organotypic brain slices

Task: Development of a bisphenol A adsorbing polymer membrane with integrated molecular shaped particles

Tutor for organic chemistry at Hochschule Furtwangen University: Planned and performed the organic chemistry tutorial for biotechnology and process engineering students

Language of Education: English

Focus: Biotechnology